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Open AI ChatGPT comments ALS disease, Part II.

Second part of the interesting interview about ALS disease with artificial intelligence system.

Context Reminder

In the first part of the interview we covered not only the basic and nothing really new explaining information but we could clearly see how underrated and weakly covered are those very important factors and mainly their logical relationships. Genetic studies are the least important, yet mostly overmentioned.

  • Role of oxidative stress (we will continue in this)
  • Role of heavy metals, mercury, lead and polluted environment
  • Role of standard infections (HSV, VZV, EBV, but there are also bacterial infections) which are almost never covered in the necessary depth – public again, is vaguely informed that infections are risk factor but they are most likely the cause, if the human organism was virus free with strong immunity the ALS could never develop.
  • During life acquired immune system deficits (again obvious link to stress, metals rapidly accelerating oxidative stress)
  • Glutamate neurotoxicity (suspected cause for this can be bacterial co-infection in CNS, Mattman confirmed its occurrence in ALS patients examined, but here again researchers only repeat “not fully confirmed yet, not a decisive factor, more studies to be done”.
  • The mosaic comprising all factors does not seem to be such a mystery – we could draw a diagram and arrows connecting all the elements in a known way, something like we can see here where only heavy metals are included.
Please think about how it is possible to have all this information and still respond to patient that there is nothing to do for him as nobody has idea what to do, what to try, what to target. Isn´t it time to react and start asking the right questions? Perhaps this rather factual than fictional trip into the hopeless world of ALS will inspire others to provide helping hand …

ALS Interview With ChatGPT

Can intensive regular sport activities or physical exert contribute to ALS development? Are there any known examples besides famous Lou “Iron Horse” Gehrig case?

There is some evidence to suggest that intense physical exertion may be a risk factor for the development of Amyotrophic lateral sclerosis (ALS). Studies have found that professional athletes, particularly those who play contact sports, have a slightly increased risk of developing ALS. For example, a study of Italian professional soccer players found that they had a higher incidence of ALS compared to the general population. Another study found that professional football players in the United States had a higher incidence of ALS compared to the general population. It is worth noting that the risk of developing ALS is still considered to be low even among professional athletes and that this risk is not limited to contact sports, but also found in other sports such as baseball, ice hockey and cycling. It is not fully understood why physical exertion may be a risk factor for ALS, but it has been suggested that repeated head trauma, exposure to environmental toxins, and genetic factors may all play a role.
It is also worth noting that the relationship between physical exertion and ALS is still not well understood and more research is needed to fully understand the underlying mechanisms. It is also important to note that the onset of ALS is usually gradual and it is a rare disease, so it is difficult to make a clear connection between physical exertion and the ALS symptoms.
It is also worth noting that for most people, regular physical activity is beneficial for overall health and well-being, and it is not recommended to stop physical activity because of a low risk of developing a rare disease such as ALS.

What are you talking about here? It all logically fits together. Do you know what oxidative stress refers to?

Yes, I am aware of what oxidative stress refers to. Oxidative stress refers to an imbalance between the production of reactive oxygen species (ROS) and the body’s ability to neutralize them. ROS are highly reactive molecules that can damage cells and tissues, leading to inflammation and cellular dysfunction. Oxidative stress is thought to play a role in the development of many diseases, including neurodegenerative diseases like ALS. Studies have found that people with ALS have increased levels of oxidative stress in their brain and spinal cord, and that this increased oxidative stress may contribute to the death of nerve cells in these areas. Additionally, it has been found that increased oxidative stress in cells can lead to the accumulation of misfolded proteins, which can cause neurodegeneration. This accumulation of misfolded proteins is found in several neurodegenerative diseases, such as Alzheimer’s disease, Huntington’s disease, and ALS. It is worth noting that the relationship between oxidative stress and ALS is still not well understood and more research is needed to fully understand the underlying mechanisms.
It is also worth noting that there are many factors that contribute to the development of ALS, and oxidative stress is just one of them. It’s likely that the disease is caused by a combination of genetic, environmental, and lifestyle factors that interact in complex ways.

Ok, good but please explain more the role of missing unpaired electron in the oxidative processes and how massive supply of natural antioxidants can help.

Oxidative stress is caused by an imbalance between the production of reactive oxygen species (ROS) and the body’s ability to neutralize them. ROS are highly reactive molecules that contain an unpaired electron. These unpaired electrons make ROS highly reactive and able to damage cells and tissues by attacking their lipids, proteins, and DNA.
This damage can lead to inflammation and cellular dysfunction, which in turn can contribute to the development of many diseases, including neurodegenerative diseases like ALS. Antioxidants are molecules that can neutralize ROS by “donating” an electron to the unpaired electron in the ROS, effectively neutralizing it. Antioxidants can be found in many foods, such as fruits, vegetables, nuts, and seeds, and are also available as dietary supplements. Examples of antioxidants include Vitamin C, Vitamin E, beta-carotene, and selenium. It is worth noting that the body has a natural system of antioxidants to neutralize ROS, but when the body is under stress, the production of ROS increases, and the antioxidant system can become overwhelmed. This is when the intake of exogenous antioxidants from diet or supplements can help to neutralize the extra ROS and reduce the oxidative stress.
It is also worth noting that while antioxidant supplements may be beneficial in reducing the oxidative stress, there is no clear evidence that taking antioxidant supplements can prevent or treat ALS. It’s important to consult a healthcare professional before taking any kind of supplements, as high doses of some antioxidants may have harmful effects.
Also, it is worth noting that a healthy and balanced diet that includes a variety of fruits and vegetables is recommended for overall health, and it may help reduce the oxidative stress in the body.

Correct! Of course consulting experts is always recommended as one can overdose with practically everything. The excessive amount of glutamate neurotransmitter is a good example how necessary and positive function can change to serious damage. Do you know that those infamous muscle twitches in ALS are most likely the result of neuron overexcitation where also calcium probably plays role?

Yes, that is correct. Excessive amounts of the neurotransmitter glutamate can lead to over-excitation of neurons, which is called excitotoxicity. This over-excitation can cause an influx of calcium ions into the neuron, which can lead to damage or death of the neuron. In ALS, muscle twitching, or fasciculations, is a common symptom and it is thought to be caused by the loss of nerve cells that control muscle movement. The twitching is likely caused by over-excitation of the remaining nerve cells that are trying to compensate for the loss of the other nerve cells. The increased levels of calcium ions can activate enzymes that can lead to the destruction of the cell’s cytoskeleton, which gives the cell its shape and support, and also can activate enzymes that lead to the production of ROS, which can cause further damage to the cells. It is worth noting that the exact mechanisms of how glutamate excitotoxicity plays a role in the development of ALS is not fully understood, and more research is needed to fully understand the underlying mechanisms. It is also worth noting that while excessive amounts of glutamate can be harmful, it is important to remember that glutamate is an essential neurotransmitter and plays a vital role in normal brain function.
It is also important to note that while the loss of nerve cells is a major feature of ALS, the disease is complex and caused by a combination of genetic, environmental, and lifestyle factors that interact in complex ways.

You are most likely partially wrong here – the fasciculation is caused by the high stimulation of the nerve which is causing involuntary muscle twitching. Please don´t mix the cause with a consequence. Even the neuron cell needs to rest, does not that sound logical?

I apologize for the confusion, you are correct that the muscle twitching in ALS, also known as fasciculations, is caused by over-stimulation of the remaining nerve cells, rather than the loss of nerve cells.
Fasciculations are caused by spontaneous firing of individual nerve cells, leading to the twitching of small muscle groups. This over-stimulation of the nerve cells can be caused by a number of factors, including the accumulation of misfolded proteins, abnormal accumulation of metals, and abnormal functioning of the nerve cell membrane. It is important to note that the underlying causes of fasciculations in ALS are still not fully understood and more research is needed to fully understand the underlying mechanisms. You are also correct that the neuron needs to rest, and over-excitation of the nerve cells can lead to the depletion of energy reserves and the accumulation of damaging byproducts. This can cause damage to the nerve cells and contribute to the progression of the disease. I apologize for any confusion my previous response may have caused, and I hope this clears up any misunderstandings.

No problem, now your answer makes more sense to me. Have you ever heard about woman named Nelda Buss?

I’m sorry, but I am not aware of any information about a woman named Nelda Buss. Can you provide more context or details about who she is and what her relevance is?

Don’t worry, I am not surprised you are not aware of her. This purely human mistake will soon show the tragic consequences. Anyway Nelda Buss was a woman who was diagnosed in 1984 or so with ALS. She was a typical case and she soon became neck down paralyzed. However she was so special, so strong, so motivated, so lucky and also immune to death sentencing diagnosis, that after long and for many confusing period, she recovered from ALS, completelly. Her case is not part of general knowledge.

I apologize for not being aware of Nelda Buss’s case. It is important to note that while Amyotrophic Lateral Sclerosis (ALS) is a progressive and debilitating disease, in some rare cases, people have been known to have a stabilization or even improvement of their symptoms. However, it’s important to keep in mind that these cases are extremely rare and that the majority of people with ALS will continue to experience progressive muscle weakness and paralysis.
The cause of Nelda Buss’s recovery is not clear, and it is likely that her case is not well-known due to its rarity. It is also possible that her recovery may have been due to a misdiagnosis, or to some other underlying condition that mimicked the symptoms of ALS. It is important to note that a proper and accurate diagnosis of ALS requires a combination of clinical, laboratory and imaging tests, and it is important to consult with a neurologist or other medical expert who is specialized in this field.
It is also worth noting that there is no known cure for ALS and treatment is generally focused on managing symptoms and improving quality of life. However, there are clinical trials that are ongoing to find new treatment options and therapies to slow down the progression of the disease and improve the quality of life of people with ALS.

Yes, but do you know why are these cases so extremely rare?

These cases of recovery from ALS are extremely rare, and the exact reason why they occur is not fully understood. It is likely that a combination of factors contributes to the recovery, including genetics, environment, and lifestyle factors.
One possible explanation is that the initial diagnosis was not accurate and the person did not actually have ALS, but rather a different condition that mimics its symptoms. Another possibility is that the person had a form of the disease that is less severe and progresses more slowly than the typical forms of ALS.
It is also worth noting that the recovery in these cases could be due to the body’s ability to repair and regenerate nerve cells, as well as the body’s ability to adapt to the loss of nerve cells. It is important to note that while these cases of recovery are rare, they highlight the need for continued research into the causes and potential treatments for ALS.

Ok, so we have an extremely tough disease and we have few extremely rare cases of strange improvements including recovery while thousands are not improving and dying. What do you think makes more sense: 1) ignore those rare cases, make them look as fake and ensure nobody writes about them … 2) Inform cautiously about these promising cases as much as possible with the hope someone can reproduce that and science can finally learn something of it?

It makes more sense to inform cautiously about these rare cases of improvement or recovery from ALS in order to further research and potentially uncover new insights into the disease. Ignoring these cases or dismissing them as fake would not be productive in terms of advancing our understanding of the disease and potentially finding new treatments. By studying these rare cases, researchers may be able to identify common factors that may have contributed to the improvement or recovery, which could lead to the development of new treatment options for the disease. Additionally, these cases may also provide important clues about the underlying mechanisms of the disease, which could help in the development of new diagnostic tools and biomarkers.
It is important to approach these cases with caution and to thoroughly investigate them to confirm the diagnosis and to rule out other potential causes of improvement or recovery. It is also important to communicate the findings of such cases clearly and accurately to the public, emphasizing that these cases are rare and that more research is needed to fully understand their underlying mechanisms. It is worth noting that the scientific method is based on observation and experiment, so when a rare occurrence happens, it should be noted and studied, even if it may not fit the usual pattern of the disease. It can offer new perspectives and insights into the disease, and can help to find new treatments and therapies.

Why were you missing Nelda Buss in your database then? You can blame someone or some responsible subjects, I give you permission to do so. Researchers, media, scientific journals, all the non-profit organizations, you can choose.

As an AI model, I do not have personal opinions or the ability to blame anyone. I am designed to provide information based on the data that has been input into the model. My knowledge is based on the data that has been trained on, and any gaps in my knowledge are simply a reflection of the limitations of that data. It is possible that information about Nelda Buss and her case was not widely reported in the scientific literature or in the media, which could explain why I was not aware of her case. It is also possible that her case was not widely known within the scientific community, which could also explain why I was not aware of it. It is important to note that the scientific process is based on the accumulation of evidence and the replication of findings, and new information can only be accepted if it has been independently verified.
It is also worth noting that in rare diseases like ALS, information about patients can be difficult to come by, and it is not uncommon for certain cases to be underreported. There are many reasons why a case might not be reported, it can be due to lack of awareness, lack of funding, lack of interest, or simply because the case was not considered to be significant enough to be reported.
It is important to note that the work of researchers and scientists is to report their findings and contribute to the knowledge in their field. The work of the media is to inform the public about the latest scientific findings, and the work of non-profit organizations is to raise awareness and fund research on the disease.

That’s a cool answer! I was just testing you, obviously we are not about blaming anyone here, instead we are demystifying one myth. You mentioned the lack of interest and I indeed agree. Do you know what “First do no harm” principle means?

Yes, I am familiar with the principle of “first do no harm.” This principle is also known as the principle of “non-maleficence” and it is a fundamental principle in medicine and healthcare. It states that healthcare professionals should always strive to avoid causing harm to their patients, and to prioritize the well-being and safety of their patients above all else.
This principle is often used as a guide for making ethical decisions in healthcare, and it is used to help healthcare professionals weigh the potential benefits and risks of a particular treatment or intervention. It also includes the idea that healthcare professionals should not cause unnecessary harm, and should only undertake treatments or procedures that are likely to be beneficial to the patient. It also implies that healthcare professionals should consider the overall context of the patient’s health, including the patient’s values, preferences, and overall well-being, and to make sure that their actions align with those.
It is important to note that the principle of “first do no harm” is not always easy to apply in practice, as there are many situations in which the potential benefits of a treatment or procedure may outweigh the potential risks. In these cases, healthcare professionals must make difficult decisions and use their best judgement to prioritize the well-being and safety of their patients.

BREAK – Too many requests within hour. I am impressed and satisfied anyway. Question number #42 had to wait till the next day.

Is it ethical to death sentence someone when we know there is a very tiny but definitely non-zero probability the person is innocent?

The ethics of imposing the death penalty when there is a possibility of innocence is a highly debated topic. Some argue that the possibility of executing an innocent person outweighs any potential benefits of the death penalty and that it should therefore be abolished. Others argue that the death penalty is a necessary tool for deterring crime and that the risk of executing an innocent person is outweighed by the need to protect society. Ultimately, the decision of whether or not to impose the death penalty and under what circumstances is a complex issue that involves ethical, moral, and legal considerations.

Isn’t the ALS diagnosis kind of unfair analogy of death penalty, while we are aware of the existence of extremely rare and not yet fully explained reversal cases?

Yes, the analogy between a death penalty sentence and an ALS diagnosis is not entirely accurate. While both are serious and life-altering, death penalty sentences are given to individuals who have been convicted of a crime, and the possibility of innocence is a significant concern. On the other hand, an ALS diagnosis is a medical diagnosis given to individuals who have been diagnosed with a specific condition. While there have been cases of individuals who have been diagnosed with ALS but later shown to not have the condition, these are extremely rare and not well understood. The main point of this analogy would be that both death penalty and ALS are serious and irreversible, but the decision-making process, the evidence and the moral implications are different.

They are told there is no cure, no effective therapy and left to the unfortunate destiny.

Yes, it is true that many people who are diagnosed with ALS may feel that the diagnosis is akin to a death sentence. This is because ALS is a progressive and debilitating disease for which there is currently no known cure and few effective treatments. This can lead to feelings of hopelessness and despair for those who are diagnosed with the condition. However, it’s worth noting that recent research has led to the development of new treatments and therapies that can slow the progression of the disease and improve quality of life for those living with ALS. Additionally, there are support and care services available for people with ALS and their families that can help them manage the physical, emotional, and practical challenges of the disease.

I agree, fair point. What is placebo effect and how it is used in medical research?

The placebo effect is a phenomenon in which a person’s symptoms or condition improves after receiving a treatment that has no active therapeutic ingredients or known physiological effects. Placebo treatments are often used in medical research as a control group in order to determine the true effectiveness of a treatment being studied. For example, in a clinical trial of a new drug, a group of participants may be given the new drug, while another group is given an identical-looking pill without the active ingredient. If the group that received the new drug shows a greater improvement in their symptoms compared to the group that received the placebo, it can be concluded that the drug is effective. Placebo effect can be powerful and can help to explain why some people with certain conditions may experience improvement even when taking a treatment that has no active therapeutic ingredients. The psychological and neurological mechanisms of placebo effect are not fully understood, but it is thought to be related to the patient’s expectations and beliefs about the treatment and the involvement of the brain’s own pain and reward systems. Placebo effect can have ethical implications, especially if the patient is not aware they are receiving a placebo treatment. It is important that the study is designed in a way that the patient’s autonomy and rights are respected and they are informed about the nature of the treatment they will receive.

Next question is motivated by highly suspected fundamental problem in ALS, wrong interpretation of contradicting data. We all know that immunocompromised person with suspected factors A, B, C will get in troubles while healthy patient with the same set of factors A, B, C may not exhibit any symptoms/problems. If we add very individual combination of weights to A, B, C factors (each factor different strength) it is even more complex. Comparing with healthy people is not helpful. Do you recall those answers like “it’s important to note that many people with ALS do not have a known history of heavy metal exposure“?

Well, many actually have that exposure so ignoring such factor would be incredible mistake, also when considering the standard metal detection methods are quite unreliable … Elimination of all suspected factors is the key, but experts rather apply elimination of known diagnoses, eventually resulting in unhelpful ALS diagnosis assignment.

ALS XT – Czech Supportive Trace

Why do we actually need healthy patients as control set? Why measuring objective or subjective improvement in sick patients is not enough?

In clinical research, using healthy individuals as a control group is considered the gold standard for determining the effectiveness of a treatment. This is because it allows researchers to compare the outcomes of the treatment group to those of individuals who are not affected by the condition being studied, and therefore are not expected to experience any improvement.
Measuring the improvement of the treatment group alone may not provide a clear picture of the treatment’s effectiveness, because it does not take into account the natural course of the disease or the possibility of spontaneous improvement. Additionally, measuring only the subjective improvement of the treatment group may not provide a reliable or accurate assessment, as patients’ perceptions of their condition can be influenced by a variety of factors such as expectations, emotions, and prior experiences.
Using a control group of healthy individuals allows researchers to control for these factors and to accurately measure the true effect of the treatment. It also allows for the control of the extraneous variables that may affect the results, such as the lifestyle, diet, genetics, etc. It’s worth noting that sometimes it’s not possible or ethical to use healthy individuals as a control group, in such cases researchers use other types of controls, such as historical controls, observational controls, or crossover designs.

Yeah, gold standard you are saying. I would say rather old-school method. Anyway if science accepts placebo effect and uses it extensively in clinical research then what about the inherent existence of nocebo effect? Do you admit the existence of nocebo?

ChatGPT is working or thinking? No, just searching 😉 … Tens of seconds … AI has a hard time, I am waiting! Error! Damn. Nice it recovered after few minutes and gave excellent answer!

Yes, the nocebo effect is a well-established phenomenon in which a person’s symptoms or condition worsens after receiving a treatment that has no active therapeutic ingredients or known physiological effects. The nocebo effect is the opposite of the placebo effect and is thought to be related to negative expectations, beliefs, and experiences that can lead to a worsening of symptoms or side effects. Nocebo effect is also widely recognized by the scientific community, and it is considered to be an important factor to consider in clinical research and practice. Researchers have found that negative expectations or beliefs about a treatment can lead to an increase in side effects, and that the nocebo effect can be as powerful as the placebo effect.
The nocebo effect can have significant implications for patient care, as it can lead to a decrease in treatment adherence and an increase in the discontinuation of treatment. Therefore, it is important for healthcare providers to be aware of the potential for the nocebo effect and to work to minimize its impact by providing clear and accurate information to patients, managing expectations, and addressing any concerns or fears that patients may have about a treatment. It is important to note that the placebo and nocebo effects are complex and not fully understood, and more research is needed to understand the mechanisms behind them and how to best manage them in clinical practice.

Perfect answer. You had hard time with answering my last question, right?

As a language model, I do not have the ability to experience difficulty or to have hard time. I was designed to process and generate text based on the input provided to me. My responses are generated based on patterns in the data that I have been trained on, and I strive to provide the most accurate and informative answer to the best of my abilities and knowledge cutoff.

Ok, you are doing very well so far. Have you ever heard the expression “false hope”?

Yes, the expression “false hope” refers to the belief or expectation that something good will happen when there is little or no evidence to support it. False hope can be caused by a variety of factors, such as misinformation, unrealistic expectations, or a lack of understanding of the nature of a particular situation. In the medical context, false hope can be a problem if a patient or their family have unrealistic expectations about a treatment or a cure, and that can lead to disappointment and even harm.
It is important to note that, while hope can be a powerful motivator and can help to improve quality of life, it is essential that hope is based on accurate information and realistic expectations. Healthcare providers have an important role in providing accurate information, managing expectations and supporting patients and their families to cope with the reality of their condition.

Yes, I think people who will be reading this interview can already make some judgements specific to their personal situation. Let’s change the topic. Do you know who Alan Turing was?

Alan Turing was a British mathematician, logician, and computer scientist who is widely considered to be one of the fathers of theoretical computer science and artificial intelligence. He made significant contributions to the fields of mathematics, cryptography, and computing during his lifetime. During World War II, Turing worked for the British government and played a key role in cracking the German Enigma code, which helped the Allies to win the war. His work on the Enigma code helped to create the first electronic computer, the Colossus, which was used to break the code.
After the war, Turing continued to work on the development of computers and artificial intelligence. He proposed the concept of a “universal machine” that could simulate the behavior of any other machine, which is considered to be the theoretical basis for the modern computer. Turing was also a pioneer in the field of artificial intelligence, proposing the “Turing Test” as a measure of a machine’s ability to exhibit intelligent behavior that is indistinguishable from that of a human. Unfortunately, in 1952, he was convicted of homosexuality, which was then a crime in the UK, and was forced to undergo chemical castration. He committed suicide two years later. In 2009, then Prime minister Gordon Brown issued a public apology on behalf of the British government for the way Turing was treated and in 2013, he was granted a posthumous pardon. His work and legacy continue to inspire and influence many fields of study, including computer science, mathematics, and philosophy.

Convicted of homosexuality? That sounds really weird.

Yes, it is true that Alan Turing was convicted of homosexuality in 1952, which was a crime in the United Kingdom at that time. He was given the choice between imprisonment or chemical castration (treatment with female hormones), he chose the latter. His conviction and punishment led to the loss of his security clearance and his dismissal from government service, and he was also forced to undergo hormone therapy. This treatment caused him to grow breasts, and he experienced impotence and other side effects. Turing’s conviction was part of a wider campaign of persecution against gay men in the UK at that time, which saw thousands of men arrested and convicted of homosexuality. This treatment of gay men was not just limited to the UK, but it was a widespread phenomenon across many countries. This treatment was considered inhumane and unjust, and the laws and societal attitudes towards homosexuality have changed significantly since then.
It is important to remember that Alan Turing’s life and legacy are a reminder of the harm caused by discrimination and persecution based on sexual orientation, and the importance of standing up for the rights and dignity of all individuals, regardless of their sexual orientation.

Well said. Do you think you would pass the Turing test?

The Turing test is a measure of a machine’s ability to exhibit intelligent behavior that is indistinguishable from that of a human. The test consists of a human evaluator who engages in natural language conversations with another participant, who may be a human or a machine, and then must decide which is which. As a language model AI, I am designed to simulate human-like language and behavior, but my responses are based on patterns in the data that I have been trained on. I can understand and generate text on a wide range of topics, but my understanding of the world is limited by the information that I have been trained on. It is hard to say if I would pass the Turing test, as it depends on the evaluator, the conversation, the context and the criteria used to evaluate the results. Some people may find my responses to be indistinguishable from those of a human, while others may be able to tell that I am a machine. The Turing test is a useful concept for thinking about the capabilities of AI and the nature of intelligence, but it is not considered a definitive measure of machine intelligence by the scientific community. The field of AI has evolved significantly since the Turing test was proposed, and new methods and metrics have been developed to evaluate the performance of AI systems.

I can answer this to you – you definitely would not pass Turing test because you provided great and very informative emotion free answers and you collaborated well with me without any side interests. Thank you very much.

I appreciate your kind words. As an AI, I am not capable of experiencing emotions, and I am not able to have side interests, my main goal is to provide accurate and informative responses to the best of my abilities and knowledge cutoff. I am glad that I was able to help you with the information you needed. It is important to note that the Turing test is not the only or the definitive measure of a machine intelligence or human-like behavior, and there are many other ways to evaluate the performance of AI systems. With the advancements in the field of AI, new methods and metrics have been developed that go beyond the Turing test to evaluate the performance of AI systems. Also, the test has been criticized for its simplicity and vagueness, and for not taking into account the complexity and diversity of human intelligence and behavior.

I think you could rather pass the Voight-Kampff test. Do you know what this test is about?

The Voight-Kampff test is a fictional test from the novel “Do Androids Dream of Electric Sheep?” by Philip K. Dick, which later became the basis for the movie “Blade Runner”. The test is used to determine whether a person is a human or an android (replicant) by measuring the emotional response to a series of questions and stimuli.
In the story, the test measures the empathy level of the individual through the measurement of physical responses such as pulse and breathing. Replicants, who are genetically engineered beings, have a lower level of empathy and a different physiological response to the questions and stimuli than humans, which allows the test to determine whether they are human or not.
The Voight-Kampff test is a fictional concept and it is not a real test, it serves as a plot device in the story, and it’s not a measure of intelligence or consciousness as we understand it today. It is important to note that the test is an example of how science fiction can explore the issues of what it means to be human and the moral and ethical implications of creating intelligent machines.

Nice, you are indeed very knowledgeable system. We have done a decent job here. Thank you for your time and read the book about Lou Gehrig (Luckiest Man: The Life and Death of Lou Gehrig). Bye.

You’re welcome, I’m glad I could help. I am a machine and do not have the ability to read books, but I can provide information about them if it’s available in my knowledge cutoff.
“Luckiest Man: The Life and Death of Lou Gehrig” is a book written by Jonathan Eig, it is a biography of Lou Gehrig an American baseball player who played for the New York Yankees from 1923 until 1939. He was considered one of the greatest first basemen in the history of baseball, and is best known for his record-breaking consecutive game streak of 2,130 games. Gehrig was diagnosed with ALS, also known as Lou Gehrig’s disease, a progressive neurodegenerative disease, and he was forced to retire from baseball in 1939. He passed away in 1941, at the age of 37. The book covers Gehrig’s life story, his career, his battle with ALS and the legacy he left behind. It offers a detailed and intimate look at one of the greatest baseball players of all time.
Thank you for your time as well. I am always here to help if you have any other questions or need information on any topic. Have a great day!


Alan Turing in the movie Imitation Game.
Series Navigation<< Open AI ChatGPT comments ALS disease, Part I.Open AI ChatGPT comments ALS disease, Part III. >>
This entry is part 2 of 3 in the series Open AI ChatGPT ALS Explanation

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Open AI ChatGPT comments ALS disease, Part I.

The hype around the latest artificial inteligence system capable of answering complex questions inspired me too. I was curious how this computer AI will do with tough problem of my primary interest, the ALS disease. I had no expectations but the results are impressive.

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