This is similar to the bacteria question. For example there is study which clearly found high levels of HERV virus in ALS patients. It is known these virus strains exist. Everyone today knows that virus mutations occur and can cause problems. What is very strange for me is that it is known there is variant of the virus which can target motor neuron – it somehow prefers some receptor of this type. Usually the cell receptors are not unique across the whole human body including all those various tissues. Naturally we can deduct one virus adapted to certain environment can be harmless but if by any accident it gets to completelly different part of the body and unfortunatelly shares the same receptor type (I call that a collision) then what would you expect to happen? I would expect it can become more virulent and target that new type of tissue because of the identical receptor. Who´s the next turn? Of course immune system needs to react and protect the invaded tissue – by destroying the infected cells. If science would not recognize it then it would state autoimmune reaction. Is this happening in ALS? Of course it is, science blames astrocytes for killing neurons. So I repeat there is a study which confirmed these viruses, normally residing in intestinal tract, could somehow get to central nervous system (CNS). There are some ways considered how it could happen. However what is alarming for me is the following fact – despite of this finding, there was some follow up study with different method and using this modified method no viruses were found. Before, they were and then they were not. The conclusion is it is not reliable finding and thus nothing to further investigate.
What? What? Whaaaaaaaaaaaaaaaaaaaaaaaaaat? I hope you are screaming now. When I read about such sloppy conclusion I thought someone is kidding me but anyway, it seems it is like that. Please read about it in my “very lucky post” here. I can only add that I am either missing something or it is insanely bad approach to the problem or it is obvious cover-up. Simply not convenient to sniff around this, similarly as with bacteria.
Do you think there is any historical lesson on accidental virus traveling inside of the organism which results in disaster? I guess you know I would not ask if not. There is a lesson with polio virus, a common virus which can cause paralysis (nervous system?) if accidentally gets to places it does not know so well. At least this is how Frank Ryan explains that in his book. References here (bottom). One citation follows.
Only in a tiny minority does the virus make its way to the anterior horn nerve cells in the spinal cord, where infection and subsequent death of the nerve cells gives rise to the paralysis we saw in President Roosevelt. Bizarre as it might seem, the infection of the nerve cells appears to serve no purpose as far as virus transmission or evolutionary pathways are concerned. Indeed this most dreaded complication of poliomyelitis appears to be coincidental [Frank Ryan: Virusphere].
Hmmm I still want to add something – I personally suspect also VZV or EBV virus or both (or the whole herpetic family gang!) but this is my personal experience (mother, myself). EBV presence has been confirmed in glial cells and VZV I mainly suspect to cause damage in PNS – the first problems with hand, fingers or leg, I would assign to this virus which targets nervous tissues (if you wanted to check my forearm, you could see it can be typical VZV blister). The problem with ALS is that we cannot think in that simple way. ALS is a multi-factor syndrome and it is a layered problem. Only one layer of many, the microbial layer can and most likely does comprise more virus types or more bacteria strains. It can be sort of microbial mosaic or puzzle. Exists something like that or am I just crazy dude? Of course it exists, it is called human microbiom. This is the mosaic and progressive scientists are learning how “guts modulate immunity” – as always other colleagues are criticizing them and questioning the new ideas while insisting on their old-school theories which have not explained nothing whatsoever (in ALS).
What can be even more confusing for today old-school scientists is that the effects of viral infection can be actually generalized. This would mean that in one patient – that partial damage to the organism is done by VZV and in other patient the generic partial damage, most likely to immunity, is done by different virus. Another very advanced part of the problem can be something I would call viral polymorphism – this basically describes virus capability to behave in very broad way. For instance there can be virus which is well known, described and considered 100% understood. It causes certain known health problem. But the same virus can under different and unique combination of environmental factors behave very differently and cause extremely serious damage. The lack in knowledge of these capabilities leads to underestimating the virus potential. For example when patient is screened from immunity point and this virus presence is detected it can confuse science – it can be interpreted like there is some basic minor cofactor infection which is not a problem. Big mistake! Every virus with known damaging behavior is problem. In the context of ALS I suspect this neglecting of the potential is concerning VZV – very dangerous virus, it is not only about shingles (low severity issue). It targets nervous tissues and due to its silent and creepy progression where no visible symptoms like skin disorder or fever are apparent, it can gradually cause serious troubles. Why I suspect it? ALS starts often in hand – patients are at first treated with carpal tunnels or some other problem but unsuccessfully. In case of misdiagnosis there can be actually loop of VZV Vs immunity micro-battles and the result is gradual scarring of the nervous tissue. What can be the outcome here? The scars may actually disconnect some partial muscle from the nerve. This would mean the problem can start in PNS, not in CNS. I always recall my mother hand – small thumb area muscle atrophed completelly. It disappeared and she still was months ahead of ALS diagnosis. This means the problem in her PNS evolved for years.
Other such overlooked virus can be famous EBV – it is not just about infectious mononucleosis, it can have much more serious collateral damage (liver). It was detected in CNS reliably and you know where? In the glial cells – astrocytes and microglia. In other words cells which are of uttermost importance in ALS investigation. The polio virus should be big lesson for science as it has these capabilities and there are probably more such examples. One can be even COVID-19 as it is not just simple virus causing loss of smell and taste or even less severe problem (hardly noticeable). It can kill you if you meet certain criteria (weak immunity, system already overloaded prior getting infected). But here we know this – there is no mystery. What about VZV, EBV, HHV-6 etc.?
All above obviously means any classification and statistics application across patient samples will inherently fail – that is why I shout as much as I can that ALS requires different approach, different methodology. Nobody is listening though. But wait for it – the revolution has already started, you just need to give helping hand and share this information.
Please note this answer is part of FAQ page containing 45+ amyotrophic lateral sclerosis (ALS) related questions. It can be also viewed as single post which may look little bit odd. For example search engine like Google or Bing can direct you at such view. If you are missing a context check the parent page and perhaps also other questions. Do you know ALS Experimental Theory? Are you aware of ALS 1KD Challenge? Have you read results of my ALS investigation with really controversial conclusion?
Fight against ALS disease needs to be lead by employing below generic tactics (details are part of this website too):
- Stabilization of PH across all body fluids
- Excretion of heavy metals (mercury, lead, cadmium) and toxic metals (aluminium) from body via natural chelatation and detoxification procedures
- Supporting immune system using all known means (supplementation, natural immune boosters)
- Supporting ALS ill organism with radical diet ("Kernel mode diet") with rich antioxidant and quality nutrition components
- Putting special focus on resting, breathing exercises, regulated sun exposure, keeping healthy and positive morale
- Support from other people who need to be also positive and believe in real improvements, words like fatality, incurability are forbidden and forgotten words
- Avoiding all strenuous activities and focusing on regulating all types of stress as much as possible (physical stress, psychic stress)